Epigenetics
VTRNA2-1: an environment-sensitive human epiallele
Open access · cc by · source: Europe PMC
Independent genome-wide methylation screens converge on VTRNA2-1 as a systemic metastable epiallele shaped by periconceptional environment and stable for years.
How this study connects
Role on claims
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VTRNA2-1 shows concordant multi-tissue methylation differences, is partly set by periconceptional environment, and remains stable ≥10 years; ME regions are depleted for CGIs/SINEs and enriched for LINEs/ERVs.
Evidence for the claim as stated.
Independent genome-wide screens for systemic interindividual methylation converged on VTRNA2-1: concordant multi-tissue differences, partly set by periconceptional environment (season of conception in Gambian infants), and stable for at least 10 years. Metastable epiallele regions were depleted for CGIs/SINEs and enriched for LINEs/ERVs. Epiallele status is not itself proof of disease causation in every tissue.
Evidence for the claim as stated.
Bisulfite designs here are not one map. VTRNA2-1 is a multi-tissue epiallele stable ≥10 years and sensitive to periconceptional season; the ageing paper compresses 102 AR-CpGs into a 3-site blood clock (MAD 3.34 years); Yoruba 27K arrays link methylation to genetics and expression in 77 LCLs. A clock CpG is not an environment-set metastable epiallele.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Bisulfite designs here are not one map. VTRNA2-1 is a multi-tissue epiallele stable ≥10 years and sensitive to periconceptional season; the ageing paper compresses 102 AR-CpGs into a 3-site blood clock (MAD 3.34 years); Yoruba 27K arrays link methylation to genetics and expression in 77 LCLs. A clock CpG is not an environment-set metastable epiallele.
- Supports · Three CpGs track blood aging
- Supports · Genetics shapes methylation and expression
Study at a glance
- Design
- Other — Multi-tissue metastable-epiallele screens plus Gambian season-of-conception methylation analyses
- N
- N=215 · Season-of-conception contrast: 110 dry-season vs 105 rainy-season conceptions; additional multi-tissue discovery screens
- Population
- Human multi-tissue DNA methylomes and Gambian infant cohorts
- Outcome
- Systemic interindividual methylation at VTRNA2-1 and periconceptional environment effects
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Inspect source passages
VTRNA2-1: an environment-sensitive human epiallele
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Methylation at this epiallele is stable over at least 10 years.
Further, we demonstrated that this is partially determined by periconceptional environment, and is stable over at least 10 years.
Why screen multiple embryonic-lineage tissues?
screening for concordant variation in multiple tissues representing different embryonic lineages, is unique in enabling the identification of systemic interindividual variation [].
Key findings
VTRNA2-1 shows concordant multi-tissue methylation differences, is partly set by periconceptional environment, and remains stable ≥10 years; ME regions are depleted for CGIs/SINEs and enriched for LINEs/ERVs.
Methodology
Authors screened multi-tissue DNA methylomes for systemic interindividual variation, then tested season-of-conception effects in Gambian infants, converging on VTRNA2-1.
Limitations
Epiallele status is not itself proof of disease causation in every tissue; screens have genomic biases despite being genomewide.
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