Critical care
How does cisplatin scramble rat hippocampal memory circuits?
Open access · cc by · source: Europe PMC
Cisplatin cut survival, impaired recognition memory, and ramped hippocampal inflammation, oxidative stress, and glutamate-receptor mRNA.
Study at a glance
- Design
- Animal / in-vitro — Male Wistar rats randomized to control vs cisplatin (8 mg/kg i.p. ×3) with survival, YMT/NORT, and hippocampal inflammatory/oxidative/glutamatergic assays
- N
- N=20 · 10 control + 10 cisplatin; some assays report n=6 survivors/completers
- Population
- Eight-week-old male Wistar rats
- Outcome
- Survival, body weight, memory behavior, and hippocampal inflammation/oxidative/glutamatergic markers
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Key findings
Survival fell to 40%, weight dropped, NORT exploration declined, and NF-κB/TNF-α/IL-6 rose with oxidative stress and glutamatergic receptor overexpression—supporting a neuroinflammation–glutamate mechanism for chemo-brain.
Methodology
Twenty rats were split into control vs cisplatin (8 mg/kg i.p. every 2 days ×3). Investigators tracked survival/weight, ran Y-maze and novel-object tests, then assayed hippocampal cytokines, ROS/antioxidant markers, mitochondrial complex I, lipid peroxidation, and AMPAR/NMDAR mRNA.
Limitations
Not a human cognitive trial; high experimental dosing and mortality limit direct clinical dose translation.
How this study connects
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