Gene expression
Do miRNAs plus cytokines flag deadly COVID-19?
Open access · cc by · source: Europe PMC
In 166 hospitalized COVID-19 patients, combining 171 microRNAomes with 25 cytokines discriminated severe disease better than either alone; CCL20, IL6, IL10, and miR-451a were key fatality correlates.
Study at a glance
- Design
- Cohort — Two-centre UK COVID-19 cohort integrating circulating microRNAomes with 25 cytokines/chemokines, including leftover hospital blood
- N
- N=166 · 166 patients (Cohort 1 n=58 with 171 microRNAomes; Cohort 2 n=108); 337 samples from 4 hospitals
- Population
- Hospitalized COVID-19 patients in two UK centres (including leftover-blood sampling)
- Outcome
- Discrimination of severe vs milder COVID-19 and correlates of fatal disease (CC + miRNA signature)
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Key findings
miRNA+CC classified severe cases more accurately than miRNA or CC alone. Severity-specific miRNA–CC links (e.g., IL6, CCL20) separated patients with similar cytokine levels. An 8 CC / 3 miRNA fatal-disease signature included CCL20, IL6, IL10, and miR-451a. Leftover hospital blood was feasible.
Methodology
Profiled 171 microRNAomes and 25 cytokines/chemokines in 58 Cohort-1 patients, then tested leftover-blood CC/miRNA profiling in 108 Cohort-2 patients from another centre (337 samples, 4 UK hospitals).
Limitations
Associations in hospitalized UK patients do not prove these miRNAs cause death or that the signature should triage care without prospective validation.
How this study connects
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