Curated scientific intelligence
Developments across the published libraries, ranked by evidence, connection, and — if you follow topics — relevance to you. Each card is a movement in the literature: what changed, how the evidence is labeled, and why it matters.
Each development carries an evidence label. What the labels mean
Latest is ordered by when PaperFren added the explanation, not by the study's original publication date.
Reaction screening · Mass spectrometry
What changed
Throughput rises by orders of magnitude and reagent consumption falls to sub-microgram. Qualitative reproducibility degrades at the fastest settings, and translating a DESI hit into an optimised preparative yield is not demonstrated here.
Machine learning · Electronic structure
What changed
A surrogate reaches useful accuracy and ships with a domain-of-applicability test. The model covers octahedral first-row complexes with the trained ligand set, descriptors ignore three-dimensional interligand clashes, and cyclams and early metals are explicit outliers.
Catalysis · Single-atom catalysts
What changed
An isolated-site catalyst delivers the selectivity that particle surfaces cannot. The structure was determined before and after reaction rather than during it, so the working state of the site remains an inference.
Photoredox · Reaction mechanism
What changed
At least these three reactions propagate chains, and the community's standard control does not detect them. The authors are explicit that this does not make every photoredox reaction a chain process.
Amyloid · Self-assembly
What changed
The products are separate and structurally distinguishable, while a kinetic interaction persists at the nucleation step. Atomic structures of mixed oligomers are not solved, and disease relevance is inferred from peptide biophysics rather than from patients.
Noncovalent interactions · Electronic structure
What changed
Orbital mixing carries a large share of the binding energy, and the trend across halide acceptors can invert. These are gas-phase model trihalides, so the argument is about where the energy comes from, not a prediction for crystals or protein sites.