Topic
Antimicrobial resistance research, explained
6 open-access antimicrobial resistance studies, each with a flashcard deck and a quiz.
- How are newborns with sepsis treated, and who is most likely to die?
Across 11 mostly low- and middle-income countries, newborns with sepsis received hundreds of different antibiotic combinations that often departed from WHO guidance, many infections resisted recommended drugs, and a simple bedside score picked out babies at high risk of death.
- Does antibiotic resistance kill children with blood infections?
In a Tanzanian children's hospital, bloodstream infections that the standard antibiotics could not treat because of resistance independently predicted death.
- Which bacteria cause blood infections in cancer patients, and resist drugs?
In one Iranian cancer hospital, most blood infections were caused by gram-negative bacteria, carbapenem resistance grew each year, and about one in five patients with these infections died.
- How common is isoniazid-resistant TB, and which mutations cause it?
About 7.4% of new TB patients worldwide have TB resistant to isoniazid but not rifampicin, a form that current rifampicin-based rapid tests miss, and most cases are explained by a single katG mutation.
- How has childhood shigellosis in Vietnam changed over 14 years?
Over 14 years the dominant cause of childhood dysentery in southern Vietnam switched from S. flexneri to S. sonnei, resistance to key drugs like ceftriaxone rose, and admitted children appeared more severely ill.
- Who gets carbapenem-resistant Klebsiella, and does it kill more?
In one Brazilian hospital, longer use of a central venous catheter was the only independent risk factor for carbapenem-resistant Klebsiella infection, and resistance came from porin loss plus ESBL enzymes rather than a carbapenemase.