Topic
chemical-biology research, explained
1 open-access chemical-biology studies, each with a flashcard deck and a quiz.
- Can alkenyl oxindoles recruit a new E3 ligase for PROTACs?
Alkenyl oxindole PROTAC ligands recruit CRL4-DCAF11 to degrade targets like BRD4; lead HL435 reached >99% Dmax with nanomolar DC50 in breast cancer cells.