Topic
Critical care research, explained
7 open-access critical care studies, each with a flashcard deck and a quiz.
- Two blood gene signatures track sepsis outcomes
In UK ICU adults with pneumonia sepsis, leukocyte transcriptomes split into SRS1 (immunosuppressed, ~41%) and SRS2; SRS1 had roughly 2–3× higher 14-day mortality, and a 7-gene set classified the groups.
- Is severe COVID linked to leaky-gut plasma markers?
Severe COVID-19 showed higher tight-junction permeability and bacterial/fungal translocation markers that tracked systemic inflammation; zonulin was higher in patients who later died.
- Genetic IL-6 receptor blockade links to lower sepsis risk
Mendelian randomisation treating IL6R variants as a natural experiment for receptor blockade found lower odds of sepsis (OR 0.80) and critical-care sepsis (OR 0.48) in UK Biobank, with a similar-sized protective association for severe COVID-19.
- Does ICU sedative Dex blunt kidney ferroptosis after I/R?
In mice and kidney cells, dexmedetomidine lessened ferroptosis-linked renal I/R injury by restraining ACSL4 through α2-AR.
- Which cell-death programs drive septic acute lung injury?
This review maps how unbalanced autophagy, ferroptosis, and pyroptosis worsen sepsis-induced ALI and which drugs might retune them.
- Three blood metabolites flag sepsis-associated kidney injury early
Mouse kidney multi-omics plus a 56-patient serum cohort produced an IC3 model (inosine, creatine, 3-hydroxybutyric acid) that early-identified sepsis-associated AKI with AUC 0.90.
- How does cisplatin scramble rat hippocampal memory circuits?
Cisplatin cut survival, impaired recognition memory, and ramped hippocampal inflammation, oxidative stress, and glutamate-receptor mRNA.