Genetics shapes methylation and expression
In HapMap LCLs, promoter methylation associates with genetic variants and transcript levels.
Source
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Study at a glance
- Design
- Cross-sectional — Illumina 27K promoter methylation in Yoruba HapMap LCLs linked to genotypes and RNA-seq
- N
- N=77 · 77 LCLs; RNA-seq available for 69
- Population
- HapMap Yoruba lymphoblastoid cell lines
- Outcome
- Genetic and expression correlates of inter-individual DNA methylation
Structured fields used in claim comparison tables when every cited study has a complete layer.
What they did
Illumina 27K methylation in 77 Yoruba LCLs related to genotypes and RNA-seq.
What they found
Inter-individual methylation variation tracks genetics and correlates with expression.
The limits
What it doesn't show
LCLs are transformed lines, so results may differ from primary tissues.
Key terms
- LCL
- Lymphoblastoid cell line.
- meQTL
- Variant associated with methylation.
- Promoter methylation
- CpG methylation near TSS.
- HapMap YRI
- Yoruba panel.
- Bisulfite array
- Illumina methylation chip.
- eQTL link
- Methylation–expression coupling.
Flashcards
Research intelligence for this paper
See its role on concept claims, tensions it is part of, placement history, and related discoveries.
Quiz yourself
Topic:
Common questions
Samples?
77 YRI LCLs.
Array?
Methylation27.
Expression?
RNA-seq.
Human?
Yes.
More on Epigenetics