Holstein GWAS across 31 dairy traits
Genome-wide SNP association in U.S. Holsteins links many loci to production, health, fertility, and type traits.
Source
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows
Study at a glance
- Design
- Computational / modelling — GWAS of ~46k SNPs against PTA traits in contemporary US Holsteins
- N
- N=1654 · 1,654 Holstein cows; 45,878 genotyped SNPs
- Population
- Contemporary US Holstein cattle with predicted transmitting abilities
- Outcome
- Additive SNP associations with production, health, and reproduction traits
Structured fields used in claim comparison tables when every cited study has a complete layer.
What they did
Tested ~46k SNPs for additive effects on PTA traits and ranked top associations per trait.
What they found
Thousands of genome-wide significant additive effects; many top SNPs fall in genes; some SNPs are pleiotropic.
The limits
What it doesn't show
PTA-based phenotypes are processed breeding values, not raw farm records.
Key terms
- GWAS
- Genome-wide association study.
- SNP
- Single-nucleotide polymorphism.
- PTA
- Predicted transmitting ability.
- Pleiotropy
- One locus affecting multiple traits.
- Holstein
- Major dairy cattle breed.
- Bonferroni
- Multiple-testing correction.
Flashcards
Research intelligence for this paper
See its role on concept claims, tensions it is part of, placement history, and related discoveries.
Quiz yourself
Topic:
Common questions
Species?
Holstein cows.
Traits?
31.
Marker set?
~46k SNPs.
Effects?
Additive.
More on GWAS