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Health behaviour

What is left 1 year after mostly non-severe COVID-19?

Zhou F, Tao M, Shang L, et al. · Frontiers in medicine · 2021

Open access · cc by · source: Europe PMC

Among 120 Wuhan survivors (~87% non-severe) followed a median 314.5 days, sleep problems, dyspnea, fatigue, joint pain, anxiety/depression, and diffusion impairment remained common.

How this study connects

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Study at a glance

Design
Cohort — Nearly 1-year follow-up of COVID-19 survivors discharged from Wuhan Union west campus and Fangcang shelters
N
N=120 · 120 SARS-CoV-2 patients; 104 (86.7%) non-severe; median 314.5 days from diagnosis to follow-up
Population
Adults discharged January–April 2020 from Wuhan designated hospital and Fangcang shelters
Outcome
Residual symptoms, anxiety/depression, IgG serostatus, lung function/CT, 6MWT, and labs ~1 year after diagnosis

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Inspect source passages

What is left 1 year after mostly non-severe COVID-19?

These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.

120 patients; 104 (86.7%) non-severe; mean age 51.6 ± 10.8 years.

The mean age of the study population was 51.6 ± 10.8 years. Of the 120 patients, 104 (86.7%) were cases of non-severe COVID-19.

Median diagnosis-to-follow-up interval was 314.5 (IQR 296–338) days.

the median time between the diagnosis and the follow-up was 314.5 (IQR, 296–338) days.
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Key findings

Mean age 51.6. Sleep difficulty, shortness of breath, fatigue, and joint pain were common; ~one-third of non-severe cases still had these. Anxiety 41.7%, depression 37.5%. 18.3% IgG-negative (20.2% non-severe vs 6.3% severe). Diffusion impairment in 26.1% (24.2% of non-severe).

Methodology

Reassessed 120 discharged patients with symptom/QoL/psychology questionnaires plus spirometry, chest CT, 6MWT, blood tests, and IgG ~1 year after diagnosis (Nov 2020–Jan 2021).

Limitations

Single-center 120-person follow-up without uninfected controls cannot estimate population Long COVID incidence or prove lasting organ damage in every non-severe case.

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