Electrochemistry
FeMn single-atom nanozyme dual-readout HER2 test
Open access · cc by · source: Europe PMC
An etched FeMn–N–C nanozyme boosts peroxidase-like activity 2.03-fold and reports HER2 by electrochemistry and 808 nm photothermal readout.
Key findings
FeMn-NCetch/SAC is 2.03× more POD-active than Fe-NC/SAC. Dual electrochemical and 808 nm photothermal signals agree with a commercial HER2 ELISA (texp < 2.78).
Methodology
Authors pyrolyzed ZnO@ZIF-8 to N-doped carbon, doped Fe/Mn, etched defects, assayed TMB/H2O2 POD activity, built a sandwich immunoassay, and compared five hospital sera to ELISA.
Limitations
This is a five-sample serum comparison, not a multicenter diagnostic trial; ‘biotherapeutic’ potential is speculative.
How this study connects
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Evidence for the claim as stated.
An etched FeMn–N–C nanozyme boosts peroxidase-like activity 2.03-fold and reports HER2 by electrochemistry and 808 nm photothermal readout.
Evidence for the claim as stated.
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