brain-development
Do mouse sex differences in brain volume match humans?
Open access · cc0 · source: Europe PMC
Human males have larger/more variable total brain volume (mice do not); after TTV control, sex-effect sizes across 60 homologous regions correlate modestly (r=0.30), higher in cortex, tracking congruence of 2835 homologous genes.
Study at a glance
- Design
- Cross-sectional — Comparative structural MRI of sex differences in human and mouse brains plus regional gene-expression congruence
- N
- N=1522 · Humans 597F/496M; mice 213F/216M (TTV analysis)
- Population
- Healthy young adult humans and mice with homologous regional atlases
- Outcome
- Cross-species congruence of volumetric sex effects and linked gene-expression profiles
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Key findings
Humans: males ~13.5% larger TTV; mice: no significant TTV sex difference. After TTV correction, ~65.8% of human and ~58.6% of mouse regions showed sex differences. Cross-species volumetric sex-effect congruence r=0.30 overall (cortex r=0.33; non-cortex r=0.16), aligning with expression congruence of 2835 homologous genes especially in primary sensory cortex.
Methodology
Used structural MRI to compare sex differences in total and regional volumes between humans and mice, then related regional volumetric sex-effect congruence to cross-species gene-expression profiles.
Limitations
Congruence is correlational and atlas-dependent; it does not prove shared developmental mechanisms for every homologous region.
How this study connects
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