Functional connectivity
Which brain networks misfire in visual snow?
Open access · cc by · source: Europe PMC
In 24 VSS patients vs 24 controls, seed-based fMRI showed widespread hyper/hypoconnectivity across visual, attentional, and salience systems at rest and during visual input.
How this study connects
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Study at a glance
- Design
- Case-control — Seed-based fMRI connectivity in VSS vs matched controls at rest and with visual stimulus
- N
- N=48 · 24 VSS + 24 matched healthy volunteers
- Population
- Adults with visual snow syndrome and matched controls
- Outcome
- Between-group functional connectivity of visual/attentional/salience seeds
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Which brain networks misfire in visual snow?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
24 VSS patients and 24 matched controls.
Twenty‐four patients with VSS and an equal number of gender and age‐matched healthy volunteers attended MRI sessions
Eight unilateral seed regions selected a priori.
Eight unilateral seed regions were selected a priori based on previous observations and hypotheses
Key findings
Altered visual-network connectivity, thalamus/basal ganglia–lingual links, visual motion network coupling to DMN/attention, plus reduced salience connectivity and V5–precuneus coupling during sensory input.
Methodology
Acquired whole-brain functional connectivity maps at rest and during a visual-snow-like stimulus using eight a priori unilateral seeds.
Limitations
Connectivity differences are not proof of causal mechanism or a treatment target trial.
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