Functional connectivity
Which brain networks misfire in visual snow?
Open access · cc by · source: Europe PMC
In 24 VSS patients vs 24 controls, seed-based fMRI showed widespread hyper/hypoconnectivity across visual, attentional, and salience systems at rest and during visual input.
Study at a glance
- Design
- Case-control — Seed-based fMRI connectivity in VSS vs matched controls at rest and with visual stimulus
- N
- N=48 · 24 VSS + 24 matched healthy volunteers
- Population
- Adults with visual snow syndrome and matched controls
- Outcome
- Between-group functional connectivity of visual/attentional/salience seeds
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Key findings
Altered visual-network connectivity, thalamus/basal ganglia–lingual links, visual motion network coupling to DMN/attention, plus reduced salience connectivity and V5–precuneus coupling during sensory input.
Methodology
Acquired whole-brain functional connectivity maps at rest and during a visual-snow-like stimulus using eight a priori unilateral seeds.
Limitations
Connectivity differences are not proof of causal mechanism or a treatment target trial.
How this study connects
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