neuroimaging
Can FDG PET spot prodromal DLB vs AD?
Open access · cc by · source: Europe PMC
In MCI converters, DLB-like hypometabolism (including substantia nigra) with preserved medial temporal/posterior cingulate metabolism, and a medial temporal/SN ratio (94% sens / 83% spec), distinguished future DLB from AD.
Study at a glance
- Design
- Cohort — Baseline FDG PET in MCI converters to DLB vs AD vs CU controls
- N
- N=158 · MCI-DLB n=17; MCI-AD n=41; CU controls n=100
- Population
- Mayo ADRC MCI patients who later met probable DLB or AD, plus CU controls
- Outcome
- FDG PET hypometabolism patterns and CIS / medial temporal–SN ratios distinguishing prodromal DLB vs AD
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Key findings
MCI-DLB showed parieto-occipital hypometabolism extending to temporal lobes, SN, and thalamus, with relatively preserved medial temporal and posterior cingulate metabolism vs MCI-AD. CIS was specific (90%) but not sensitive (59%); medial temporal/SN ratio was both sensitive (94%) and specific (83%).
Methodology
Compared baseline FDG PET in Mayo ADRC MCI patients who progressed to probable DLB (n=17) or AD dementia (n=41) versus CU controls (n=100), evaluating CIS and regional metabolic ratios.
Limitations
Small MCI-DLB n and single-center Mayo sample limit generalizability; PET patterns are biomarkers, not definitive pathologic diagnoses at the MCI stage.
How this study connects
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