Spectroscopy
UV chemometrics quantify two COVID-era drugs at once
Open access · cc by · source: Europe PMC
CLS, PCR, PLS and GA-PLS models resolve overlapping UV spectra of montelukast and levocetirizine, with GA-PLS best (R2 > 0.99) and Latin-hypercube validation plus greenness scores versus HPLC.
Key findings
GA-PLS had R2 0.9932/0.9901, RMSEP 0.1872/0.1779, LOD 0.0813 and 0.2273 μg mL−1, recoveries 99.72–100.86%. Working window is 191 wavelengths. The UV method is positioned as a greener alternative to HPLC.
Methodology
Authors recorded 210–400 nm spectra of MLK/LCZ mixtures, built four chemometric calibrations on a 25-sample Brereton design, validated with LHS, and scored NEMI/GAPI/AGREE/BAGI/RGB12 sustainability.
Limitations
It quantifies two APIs in tablets, not metabolites in plasma, and green scores are metric-based rather than a full process LCA.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Not yet placed on a claim. This paper has study layers, but no concept page yet cites it as support, challenge, or qualifier.
Related papers in this topic
Same topic cluster — not a recommendation engine.