Functional connectivity
Which arcuate fasciculus segments matter for aphasia?
Open access · cc by · source: Europe PMC
In 33 chronic left-stroke aphasia cases, left AF long/anterior/posterior segments predicted naming, fluency, and comprehension beyond cortex; right AF role was unclear.
Study at a glance
- Design
- Cross-sectional — Chronic post-stroke aphasia cohort with AF tractography and language regressions controlling for cortex/lesion
- N
- N=33 · People with aphasia after left-hemisphere stroke
- Population
- Chronic left-hemisphere stroke survivors with aphasia (VA Northern California cohort)
- Outcome
- Associations of AF segment volume/integrity with WAB/BNT language scores beyond cortical damage
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Key findings
Left long→naming; anterior→fluency/naming; posterior→comprehension; posterior emphasized for residual language; no clear right-AF contribution.
Methodology
Reconstructed left/right AF with multi-segment tractography and related normalized volume/microstructure to language scores while controlling for lesion and cortical areas.
Limitations
Causal repair from stimulating AF, or that dorsal-stream=repetition-only models are fully wrong in every patient.
How this study connects
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