Epigenetics
Which T cells lose chromosome Y most?
Open access · cc by · source: Europe PMC
Across cancer scRNA-seq and new PBMC/CD4+ data, regulatory T cells showed the highest LOY, higher Treg ratios, and 465 dysregulated genes tied to Treg programs.
Study at a glance
- Design
- Computational / modelling — scRNA-seq reanalysis + new PBMC/CD4+ datasets comparing LOY across T cell subtypes
- N
- N=55 · 23 PBMC + 32 CD4+ enriched samples in validation dataset (plus public cancer scRNA-seq)
- Population
- T lymphocyte–enriched scRNA-seq from cancer patients and new PBMC/CD4+ samples
- Outcome
- LOY burden by T cell subtype; Treg fraction and gene dysregulation with LOY
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Key findings
Tregs had significantly more LOY than other T subtypes; LOY associated with increased Treg ratio and dysregulation of hundreds of immunosuppressive/developmental genes.
Methodology
Analyzed public T-enriched cancer scRNA-seq and generated 23 PBMC + 32 CD4+ enriched samples to compare LOY across T subtypes and trajectories.
Limitations
Does not prove LOY in Tregs causes cancer; observational single-cell associations.
How this study connects
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