rheumatoid-arthritis
How does METTL3 fuel rheumatoid arthritis FLSs?
Open access · cc by · source: Europe PMC
METTL3 is upregulated in RA synovium and AIA rats; it boosts FLS inflammatory mediators and activation through NF-κB signalling.
Key findings
METTL3 was significantly upregulated in human RA synovium and the AIA model. Knockdown lowered IL-6, MMP-3, and MMP-9; overexpression raised them. Authors conclude METTL3 may promote FLS activation and inflammation via NF-κB.
Methodology
Compared METTL3 in RA vs OA synovial tissues, manipulated METTL3 in human RA-FLSs and rat AIA-FLSs, and probed inflammatory cytokines, MMPs, and NF-κB pathway activity.
Limitations
Small human tissue N (RA 5, OA 3) and mechanistic cell/animal work do not prove a clinical therapy; NF-κB is implicated but not a full patient trial.
How this study connects
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