Neurocognitive aging
Can brief brain or body training strengthen older adults' white matter?
Open access · cc by · source: Europe PMC
Ten weeks of computer brain training or exercise did not change white matter integrity in older adults at risk of dementia, even though a cognitively active lifestyle was linked to better cognitive change.
Study at a glance
- Design
- Other — Non-randomised controlled trial with matched/minimisation allocation to computerised auditory and working-memory training, multimodal physical training or a wait-list control, with DTI and cognitive testing at pretest, posttest and 3-month follow-up, plus observational analyses of self-reported lifestyle.
- N
- N=39 · 47 were allocated (13 cognitive training, 14 physical training, 20 controls); 39 were included in the analysis; training-performance analyses used only 9 people with usable data.
- Population
- Community-dwelling older adults in Germany at risk of dementia (memory complaints), heavily screened
- Outcome
- Fractional anisotropy composite of the genu of the corpus callosum, fornix and hippocampal cingulum; global cognition, episodic memory and executive function composites
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Key findings
Neither training programme changed the white matter composite compared with controls at posttest or follow-up; effect sizes were near zero and their 95% confidence intervals excluded medium effects. Lifestyles did not predict white matter change either. A more cognitively varied lifestyle did predict improvements in global cognition and episodic memory (standardised betas of at least 0.40), and this link held after accounting for white matter change. At baseline, people with better cognitive-training skill had higher white matter integrity (r = 0.68), and fitter people had higher fornix integrity (r = 0.35).
Methodology
Older adults with memory complaints were allocated (without randomisation, but matched on age, education, sex and cognitive screening score) to 50 hours of home-based auditory and working-memory training, a multimodal exercise programme, or a wait-list control. White matter integrity was measured with diffusion tensor imaging as fractional anisotropy in three tracts affected by aging and Alzheimer's disease, and cognition with a test battery, before training, right after it and three months later. Self-reported cognitive and physical lifestyles were also related to changes in brain and cognition.
Limitations
Allocation was not randomised, participants could not be blinded, and the analysed sample was small (39 people, with training-skill analyses on only 9), so small effects could easily be missed. Only three pre-chosen tracts were examined, so changes elsewhere, for instance in motor tracts that exercise is known to affect, would be invisible. The training lasted only ten weeks, so the study says nothing about longer-term programmes, and the lifestyle findings are observational and cannot show cause. Baseline correlations between fitness or skill and white matter do not show that training would change the tracts.
How this study connects
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