cancer-epidemiology
Are cancers under 50 rising in the US?
Open access · cc by · source: Europe PMC
In 562,145 early-onset SEER cases (2010–2019), overall incidence rose (APC 0.28%), led by gastrointestinal cancers (APC 2.16%), while ≥50 incidence fell.
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Are cancers under 50 rising in the US?
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562,145 early-onset cancer patients analyzed.
Among 562 145 patients (324 138 [57.7%] aged 40-49 years; 351 120 [62.5%] female) with early-onset cancer
Overall early-onset APC 0.28%.
the age-standardized incidence rate of early-onset cancers increased overall (APC, 0.28%; 95% CI, 0.09%-0.47%; P = .01)
Key findings
Early-onset incidence increased overall and in females but decreased in males; cancers ≥50 declined (APC −0.87%). Breast had the most 2019 early-onset cases (n=12,649). GI cancers grew fastest (APC 2.16%), especially appendix (15.61%), intrahepatic bile duct (8.12%), and pancreas (2.53%).
Methodology
Used SEER registries to compute age-standardized incidence rates and Joinpoint APCs for cancers diagnosed before age 50 from 2010 to 2019, contrasting sex and site patterns and older-adult trends.
Limitations
Incidence trends do not identify causes (screening, risk factors, coding); APC ≠ individual risk prediction.
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