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vaccine-safety

Does a COVID mRNA booster raise myocarditis risk?

Stowe J, Miller E, Andrews N, et al. · PLoS medicine · 2023

Open access · cc by · source: Europe PMC

In England, myocarditis admissions rose mainly in males 16–39 within 0–6 days after mRNA doses (highest after dose 2); boosters still elevated risk but prior infection lowered vaccine-associated RIs.

Key findings

2,284 myocarditis and 1,651 pericarditis admissions. Elevated vaccine RIs mainly in 16–39-year-olds 0–6 days post-dose, especially males. ChAdOx1-S elevation only after first dose (RI 5.23). Prior infection lowered second-dose RIs; infection itself raised risk over 1–27 days.

Methodology

Ran a nationwide self-controlled case series comparing admission risk windows after BNT162b2, mRNA-1273, and ChAdOx1-S doses and after SARS-CoV-2 infection, stratified by age, sex, dose, and prior infection.

Limitations

Hospital-admission SCCS estimates rare absolute risks incompletely for mild outpatient cases; does not weigh COVID benefits vs risks for individuals.

How this study connects

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