Microbiome
Is the gut microbiome the same along the intestine?
Open access · cc by · source: Europe PMC
Swine mucosal and luminal microbiomes differ by gut section, with distinct diversity patterns and bile-acid/SCFA environments.
How this study connects
Role on claims
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Strain-level gene content varies a lot within the same gut species — species labels are coarse.
Even within the same named gut species, strain-level gene content varies substantially among healthy people—so species labels alone understate functional diversity.
Scope note — different scale — mucosal vs luminal niches along the gut
Limits the claim's scope: a different population, assay, or outcome.
History
When this study was placed
Dated entries from the concept change log — when this paper was added or removed as support, challenge, or qualifier on a claim.
Placed as a scope qualifier on Microbiome
Even within the same named gut species, strain-level gene content varies substantially among healthy people—so species labels alone understate functional diversity.
Study at a glance
- Design
- Animal / in-vitro — 16S profiling of paired luminal and mucosa-associated communities plus bile-acid and SCFA measurements
- N
- N=24 · 144 luminal and mucosal samples from 24 pigs
- Population
- Healthy swine intestinal tract sections
- Outcome
- Mucosal and luminal microbiomes differ by gut section in diversity, co-occurrence, and bile-acid/SCFA environments
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Inspect source passages
Is the gut microbiome the same along the intestine?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Ileal total bile acids ~3-fold higher than cecum/colon
Total bile acids in the ileum were 3-fold as much as those of the cecum and colon ( P < 0.001, Figure ).
Which phyla dominate swine gut communities here?
dominated by Firmicutes, Bacteroidetes and Proteobacteria , similar to previous findings in pigs (Looft et al., ; Mach et al., ; Sun et al., , ; Umu et al., ; Kelly et al., ; Ramayocaldas et al., ) and humans (Qin et al.
Key findings
Communities dominated by Firmicutes/Bacteroidetes/Proteobacteria; richness and α/β-diversity differ by section and lumen vs mucosa; ileal bile acids much higher than large intestine.
Methodology
Profiled luminal and mucosa-attached microbiota across swine intestinal sections and measured bile acids and SCFAs.
Limitations
Does not prove identical patterns in every human diet or disease state.
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Same topic cluster — not a recommendation engine.