developmental-neuroscience
Can a baby’s brain connectome act like a fingerprint?
Open access · cc by · source: Europe PMC
In dHCP preterm infants, structural connectomes identified individuals ~62% of the time (mean self r=0.90), while functional connectomes rarely did (~10%).
Study at a glance
- Design
- Cohort — dHCP preterm infants scanned twice (preterm + term-equivalent) for connectome fingerprinting
- N
- N=45 · 45 infants with usable structural connectomes; 31 with functional; 26 with both
- Population
- Preterm infants in the developing Human Connectome Project
- Outcome
- Within-subject vs between-subject connectome similarity / identifiability
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
Structural mean self-similarity r=0.90 and identifiability 28/45 (62.22%); functional mean self-similarity r=0.56 and identifiability only 3/31 (9.68%). Older PMA at first scan correlated with higher structural self-similarity; more days between scans reduced functional self-similarity.
Methodology
Compared structural and functional connectomes from paired preterm and term-equivalent MRI scans in the developing Human Connectome Project, quantifying self-similarity, self-to-other similarity, and identifiability, plus effects of PMA and days between scans.
Limitations
Does not prove functional networks lack individual meaning—only that early functional fingerprints are less stable/identifying across this interval than structural ones.
How this study connects
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