genetics
How does Foxj1 build smell-sensing cilia?
Open access · cc by · source: Europe PMC
In zebrafish and mice, Foxj1 is required for olfactory epithelium formation and OSN differentiation; mutants lose olfactory cilia programs and show diminished bile-acid odor responses.
Key findings
Foxj1, classically a motile-cilia factor, is expressed in OSNs and required for OE formation. Motility genes are repressed in OSNs across species. Foxj1 also controls OSN differentiation genes such as omp; foxj1 mutant zebrafish have significantly diminished bile-acid responses.
Methodology
Examined Foxj1 expression and loss-of-function phenotypes in zebrafish and mouse OSNs, including transcriptomic and odor-response readouts, and compared motility-gene repression across zebrafish, mouse, and human OSNs.
Limitations
Animal genetics do not by themselves map all human anosmia syndromes to Foxj1; exact downstream circuitry beyond highlighted targets remains incompletely charted.
How this study connects
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