Cardiovascular
How much dementia could prevention still avert?
Open access · cc by · source: Europe PMC
In Rotterdam cohorts, about one quarter to one third of dementia cases were potentially attributable to modifiable risks—and that share did not shrink over two decades.
Study at a glance
- Design
- Cohort — Rotterdam Study; population attributable risks for modifiable risks across earlier and later cohorts
- N
- N=7003 · 7,003 in original-cohort analyses; extended cohort analysed separately (n=2,953)
- Population
- Rotterdam Study participants without prevalent dementia
- Outcome
- Population attributable fraction of dementia from modifiable cardiovascular risks and education
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
Potential prevention remained roughly one quarter to one third of cases and had not declined between cohorts spanning about two decades, motivating public-health action.
Methodology
Using prospective Rotterdam Study data, investigators estimated population attributable risks for modifiable cardiovascular risks, related diseases, and education for dementia, comparing earlier and later cohorts.
Limitations
PAR estimates assume risk-factor causality and eliminability; they are not a trial proving a specific prevention package.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Multiple studies in this library examine cardiovascular care with empirical patient or population outcomes rather than opinion alone.
Evidence for the claim as stated.
Potential prevention remained roughly one quarter to one third of cases and had not declined between cohorts spanning about two decades, motivating public-health action.
Evidence for the claim as stated.
Effect sizes and settings differ across cardiovascular care studies — digital vs clinic, trial vs observational — so results should not be pooled casually.
Evidence for the claim as stated.
Rotterdam Study analyses estimated that modifiable cardiovascular risks, related diseases and education could still account for roughly one quarter to one third of dementia cases, a potential-prevention fraction that had not declined between cohorts spanning about two decades. Those PAR estimates assume risk-factor causality and eliminability; they are not a trial of a named prevention package.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Effect sizes and settings differ across cardiovascular care studies — digital vs clinic, trial vs observational — so results should not be pooled casually.
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