neuroimmunology
Does vagal TLR4 cause LPS anorexia—or mainly CGRP release?
Open access · cc by · source: Europe PMC
Restoring TLR4 only in Nav1.8 afferents did not restore LPS anorexia, but LPS still triggered CGRP release from TLR4+/CGRP+ vagal jugular neurons.
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Does vagal TLR4 cause LPS anorexia—or mainly CGRP release?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Nav1.8-restricted TLR4 insufficient for LPS rapid-onset anorexia.
Contrary to our expectations, the administration of LPS did not cause rapid-onset anorexia in mice with Na v 1.8-restricted TLR4
LPS sufficient to stimulate CGRP release in vitro.
the application of LPS to cultured Na v 1.8-restricted TLR4 afferents was sufficient to stimulate the release of CGRP
Key findings
Nav1.8-restricted TLR4 was insufficient for rapid-onset LPS anorexia; Tlr4 enriched in jugular Nav1.8/CGRP vagal afferents; LPS stimulated CGRP release in vitro.
Methodology
Built Tlr4 LoxTB mice, restored TLR4 globally (Zp3-Cre) or in Nav1.8 afferents, mapped Tlr4 with ISH, and applied LPS to cultured afferents.
Limitations
Does not map the full in vivo infection-fighting role of the LPS–TLR4–CGRP loop or test female experimental cohorts for feeding assays.
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