Cell signalling
How specific are bacterial two-component pathways?
Open access · cc by · source: Europe PMC
Caulobacter histidine kinases prefer their cognate response regulators in vitro; phosphotransfer profiling reveals conserved pathways controlling growth.
Key findings
Kinases show kinetic preference for in vivo cognate regulators; profiling identified targets such as CC0530→CC3743 and the conserved CenK–CenR envelope/growth pathway.
Methodology
Combined genetics and phosphotransfer profiling across Caulobacter two-component proteins to map kinase–regulator pairs and phenotypes.
Limitations
Does not claim every environmental input for every kinase in nature is solved.
How this study connects
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