nutrition
Does being dehydrated relate to faster cognitive decline?
Open access · cc by · source: Europe PMC
In 1957 PREDIMED-Plus adults, higher baseline serum osmolarity tracked greater 2-year global cognitive decline, while reported water intake did not.
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Study at a glance
- Design
- Cohort — Prospective PREDIMED-Plus analysis of baseline hydration vs 2-year cognition change
- N
- N=1957 · Adults 55–75 with overweight/obesity and metabolic syndrome
- Population
- Older Spanish PREDIMED-Plus participants at high CVD risk
- Outcome
- 2-year change in global cognitive function z-score
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Does being dehydrated relate to faster cognitive decline?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
1957 adults analyzed from PREDIMED-Plus.
A prospective analysis was conducted of a cohort of 1957 adults (aged 55–75)
56% physiologically dehydrated; osmolarity–cognition β −0.010.
Serum osmolarity (mean 298 ± 24 mmol/L, range 263 to 347 mmol/L) indicated that 56% of participants were physiologically dehydrated.
Key findings
Mean total water intake 2871 mL/day; 80.2% met EFSA adequacy, yet 56% were physiologically dehydrated by osmolarity (mean 298 mmol/L). Greater osmolarity associated with worse cognitive change (β −0.010; 95% CI −0.017 to −0.004). Water intake from foods/beverages was not significantly associated with cognitive change.
Methodology
Prospectively related baseline serum osmolarity categories and beverage/food water intake (vs EFSA adequacy) to 2-year change in a composite cognition z-score from eight neuropsychological tests, using multivariable linear models.
Limitations
Observational 2-year follow-up cannot prove that drinking more water prevents dementia; osmolarity may proxy broader illness/medication factors.
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