Curated scientific intelligence
Developments across the published libraries, ranked by evidence, connection, and — if you follow topics — relevance to you. Each card is a movement in the literature: what changed, how the evidence is labeled, and why it matters.
Each development carries an evidence label. What the labels mean
Latest is ordered by when PaperFren added the explanation, not by the study's original publication date.
Aging · Epigenetics
What changed
A multi-tissue clock works, which reframes methylation drift as a systemic phenomenon. It predicts age; it does not show that methylation causes aging, and its accuracy varies by tissue and disease state.
Biodiversity · Taxonomy
What changed
A method with an internal validity check narrows the range considerably. It is still a model extrapolation, it does not cover prokaryotes — whose species concept differs — and it will move as synonymy and sampling improve.
Immunology · Epigenetics
What changed
Epigenetic state at the locus, not the presence of the transcription factor, tracks whether the phenotype persists. The data are mostly from mouse, and human translation needs its own evidence.
Gene expression · Single-cell
What changed
Bursting is a property of the gene, and the intrinsic/extrinsic decomposition attributes most of the spread to the locus. The study does not map burst kinetics for every gene or in tissue, and it does not identify a single molecular switch.
Cell signaling · Development
What changed
Ligand class is a property of the ligand-receptor pair. This resolves the specific Wnt5a conflict; it does not map which receptors are actually present in any given tissue, which is what would be needed to predict the output in vivo.
Gene regulation · Prediction methods
What changed
Seed pairing became the organising rule for animal microRNA targeting. The rules are established for the microRNAs studied, and a predicted site is still not equally functional in every tissue.