Topic
Rheumatology research, explained
6 open-access rheumatology studies, each with a flashcard deck and a quiz.
- Are people with autoimmune diseases more prone to blood clots?
People admitted to hospital with a wide range of immune-mediated diseases, especially lupus and polyarteritis nodosa, later had clearly higher rates of blood clots in the veins than a comparison group.
- Do forums and game features make a health website work better?
For people with rheumatoid arthritis, adding online social support or game-like rewards to an information website increased use and empowerment and was linked to better self-reported health behaviour, while information alone did no better than no website.
- RIPK1 inhibitor GSK2982772 did not beat placebo on RA activity here
In 52 patients with moderate–severe RA on stable csDMARDs, oral GSK2982772 60 mg for 84 days was mainly assessed for safety; DAS28-CRP and ACR responses looked similar to placebo, without meaningful clinical improvement at tested exposures.
- Early RA synovium splits into two expression/histology groups
Targeted knee synovial biopsies from early RA patients clustered into two major gene-expression groups with different histological scores, showing molecular heterogeneity even early in disease.
- Seliciclib MTD is 400 mg in TNF-refractory RA (TRAFIC phase 1b)
In an open-label UK dose-finding trial of 15 TNF-refractory RA patients, the CDK inhibitor seliciclib’s maximum tolerated dose was 400 mg, aiming at synovial fibroblast proliferation rather than classic immune-cytokine targets alone.
- Can gastrodin calm RA by blocking histone lactylation?
Gastrodin bound KAT8 (KD 413.72 μM), lowered H3K9la, cut IL-6/MMP signals in FLS and THP-1 cells, and eased joint swelling in AIA rats at 20 mg/kg.