Which brain networks misfire in visual snow?
In 24 VSS patients vs 24 controls, seed-based fMRI showed widespread hyper/hypoconnectivity across visual, attentional, and salience systems at rest and during visual input.
Source
Disrupted connectivity within visual, attentional and salience networks in the visual snow syndrome
Study at a glance
- Design
- Case-control — Seed-based fMRI connectivity in VSS vs matched controls at rest and with visual stimulus
- N
- N=48 · 24 VSS + 24 matched healthy volunteers
- Population
- Adults with visual snow syndrome and matched controls
- Outcome
- Between-group functional connectivity of visual/attentional/salience seeds
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Which brain networks misfire in visual snow?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
24 VSS patients and 24 matched controls.
Twenty‐four patients with VSS and an equal number of gender and age‐matched healthy volunteers attended MRI sessions
Eight unilateral seed regions selected a priori.
Eight unilateral seed regions were selected a priori based on previous observations and hypotheses
What they did
Acquired whole-brain functional connectivity maps at rest and during a visual-snow-like stimulus using eight a priori unilateral seeds.
What they found
Altered visual-network connectivity, thalamus/basal ganglia–lingual links, visual motion network coupling to DMN/attention, plus reduced salience connectivity and V5–precuneus coupling during sensory input.
The limits
What it doesn't show
Connectivity differences are not proof of causal mechanism or a treatment target trial.
Key terms
- Visual snow syndrome (VSS)
- Neurological syndrome of continuous visual static and related symptoms.
- Functional connectivity
- Correlated fMRI activity between regions/networks.
- Salience network
- Network tracking relevant sensory/internal events; reduced connectivity here in VSS.
- Lingual gyrus
- Visual cortex region linked to thalamus/basal ganglia seeds.
- V5
- Visual motion area with altered precuneus coupling.
- Seed-based analysis
- Connectivity measured from predefined seed ROIs.
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VSS patients scanned:
Common questions
Sample?
24 VSS + 24 matched controls.
Conditions scanned?
Rest (blank screen) and visual-snow-like stimulus.
Seed count?
Eight unilateral a priori seeds.
Broad finding?
Widespread multi-network connectivity disruption.
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