Is IBD still rising in UK primary care?
Among 11.3 million UK primary-care patients, overall IBD incidence was high; rates fell in adults >40 but rose ~94% in adolescents 10–16 years.
Source
Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study
Study at a glance
- Design
- Cohort — Population-based UK primary-care cohort in IMRD, 2000–2018
- N
- N=11325025 · 11,325,025 registered individuals; 22,560 incident IBD diagnoses
- Population
- UK primary-care patients in IQVIA Medical Research Data
- Outcome
- IBD incidence trends and 2018 point prevalence (IBD/CD/UC)
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Inspect source passages
Is IBD still rising in UK primary care?
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
11,325,025 individuals; 22,560 incident IBD diagnoses.
11 325 025 individuals were included and 65 700 IBD cases were identified, of which 22 560 were incident diagnoses made during the study period.
Adolescent incidence rose from 13.1 to 25.4 per 100,000 person-years.
In adolescents aged 10–16 years, incidence rose from 13.1 (8.4 to 19.5) to 25.4 (19.5 to 32.4)/100 000 person years
What they did
Analyzed IQVIA Medical Research Data (IMRD) from 2000–2018 for recorded IBD diagnoses, estimating crude incidence of IBD/CD/UC and age-specific temporal trends plus 31 Dec 2018 point prevalence.
What they found
22,560 incident IBD cases (8077 CD; 12,369 UC). Crude incidence per 100,000 person-years: IBD 28.6, CD 10.2, UC 15.7. Incidence fell in >40s (37.8→23.6) but rose in ages 10–16 (13.1→25.4). 2018 prevalence per 100,000: IBD 725, CD 276, UC 397.
The limits
What it doesn't show
Primary-care codes without secondary-care histology/endoscopy confirmation may misclassify some cases; causes of adolescent rise remain unexplained.
Key terms
- Incidence
- New diagnoses per person-time.
- Point prevalence
- Proportion living with disease on a date.
- IMRD
- IQVIA Medical Research Data UK primary-care database.
- CD/UC
- Crohn’s disease / ulcerative colitis.
- IBDU
- IBD unclassified when CD vs UC unclear.
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Individuals in the cohort:
Common questions
Cohort size?
11,325,025 individuals.
Incident IBD cases?
22,560 during the study.
Adolescent trend?
Incidence roughly doubled (94% rise).
2018 IBD prevalence?
725 per 100,000.