Is IBD still rising in UK primary care?
Among 11.3 million UK primary-care patients, overall IBD incidence was high; rates fell in adults >40 but rose ~94% in adolescents 10–16 years.
Source
Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study
Study at a glance
- Design
- Cohort — Population-based UK primary-care cohort in IMRD, 2000–2018
- N
- N=11325025 · 11,325,025 registered individuals; 22,560 incident IBD diagnoses
- Population
- UK primary-care patients in IQVIA Medical Research Data
- Outcome
- IBD incidence trends and 2018 point prevalence (IBD/CD/UC)
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What they did
Analyzed IQVIA Medical Research Data (IMRD) from 2000–2018 for recorded IBD diagnoses, estimating crude incidence of IBD/CD/UC and age-specific temporal trends plus 31 Dec 2018 point prevalence.
What they found
22,560 incident IBD cases (8077 CD; 12,369 UC). Crude incidence per 100,000 person-years: IBD 28.6, CD 10.2, UC 15.7. Incidence fell in >40s (37.8→23.6) but rose in ages 10–16 (13.1→25.4). 2018 prevalence per 100,000: IBD 725, CD 276, UC 397.
The limits
What it doesn't show
Primary-care codes without secondary-care histology/endoscopy confirmation may misclassify some cases; causes of adolescent rise remain unexplained.
Key terms
- Incidence
- New diagnoses per person-time.
- Point prevalence
- Proportion living with disease on a date.
- IMRD
- IQVIA Medical Research Data UK primary-care database.
- CD/UC
- Crohn’s disease / ulcerative colitis.
- IBDU
- IBD unclassified when CD vs UC unclear.
Flashcards
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Quiz yourself
Individuals in the cohort:
Common questions
Cohort size?
11,325,025 individuals.
Incident IBD cases?
22,560 during the study.
Adolescent trend?
Incidence roughly doubled (94% rise).
2018 IBD prevalence?
725 per 100,000.