A MOF that releases CO with visible light
Post-synthetic Mn(CO)3 on a zirconium MOF (CORF-1) liberates carbon monoxide under low-intensity visible light, with crystal size from 260 nm to 1 mm setting the dose.
Source
Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates
Study at a glance
- Design
- Animal / in-vitro — Photoactive Mn carbonyls in UiO-67-type MOFs used as CO-releasing cell-culture platforms
- N
- Materials plus cell-culture delivery assays — no subject N
- Population
- Cultured cells grown on MOF polymer films releasing CO under light
- Outcome
- Controllable phototriggered CO release and intracellular delivery
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Inspect source passages
A MOF that releases CO with visible light
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
CORF-1 crystal size was tuned from 260 nm up to 1 mm.
Using the coordination modulation approach, the crystal size of CORF-1 could be finely tuned from 260 nm up to 1 mm, which proved to be an additional way to control the extent of CO release by the crystals.
CO was carried to the detector by N2 at 500 ml min−1.
The released CO gas from CORF-1 was carried to the CO detector (HALO 3 TM trace gas analyzer from Tiger Optics) by N 2 flow (500 ml min –1 flow rate) (Fig.
What they did
Authors immobilized photoactive manganese carbonyls in UiO-67-type bpy MOFs, tuned crystal size by coordination modulation, quantified CO with a trace-gas analyzer, and grew cells on a polymer film of the MOF to watch intracellular CO after irradiation.
What they found
Low-intensity visible light triggers controllable CO release. Crystal size from 260 nm to 1 mm changes loading and photoefficiency. Immobilized particles deliver CO into cells, addressing the localization problem of molecular photoCORMs.
The limits
What it doesn't show
NIR-triggered deep-tissue delivery and a therapeutic in vivo inflammation model are proposed, not completed; CO is still a toxic gas if mis-dosed.
Key terms
- PhotoCORM / CORF
- Photoactive CO-releasing molecule or framework that stores CO until light hits.
- UiO-67-bpy
- Zirconium MOF with bipyridine dicarboxylate linkers that bind Mn(CO)3.
- Coordination modulation
- Adding modulators to set MOF crystal size from nanometers to millimeters.
- Gasotransmitter
- Small signaling gas (CO, NO, H2S) used by cells at low dose.
- CORF-1
- The authors’ Mn(CO)3-functionalized Zr MOF CO-release material.
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Quiz yourself
CORF-1 stores CO as:
Common questions
What metal carbonyl is immobilized?
Photoactive manganese carbonyl (Mn(CO)3) in a Zr MOF.
What light is used?
Low-intensity visible light.
How is dose tuned besides light?
Crystal size from 260 nm to 1 mm.
Does CO enter cells?
Yes, from MOF particles in a polymer cell-culture substrate.
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