Coordination chemistry
A MOF that releases CO with visible light
Open access · cc by · source: Europe PMC
Post-synthetic Mn(CO)3 on a zirconium MOF (CORF-1) liberates carbon monoxide under low-intensity visible light, with crystal size from 260 nm to 1 mm setting the dose.
Study at a glance
- Design
- Animal / in-vitro — Photoactive Mn carbonyls in UiO-67-type MOFs used as CO-releasing cell-culture platforms
- N
- Materials plus cell-culture delivery assays — no subject N
- Population
- Cultured cells grown on MOF polymer films releasing CO under light
- Outcome
- Controllable phototriggered CO release and intracellular delivery
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
Low-intensity visible light triggers controllable CO release. Crystal size from 260 nm to 1 mm changes loading and photoefficiency. Immobilized particles deliver CO into cells, addressing the localization problem of molecular photoCORMs.
Methodology
Authors immobilized photoactive manganese carbonyls in UiO-67-type bpy MOFs, tuned crystal size by coordination modulation, quantified CO with a trace-gas analyzer, and grew cells on a polymer film of the MOF to watch intracellular CO after irradiation.
Limitations
NIR-triggered deep-tissue delivery and a therapeutic in vivo inflammation model are proposed, not completed; CO is still a toxic gas if mis-dosed.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
This library holds 8 empirical chemistry papers on coordination chemistry with isolated findings, rates or spectra rather than reviews.
Evidence for the claim as stated.
Post-synthetic Mn(CO)3 on a zirconium MOF (CORF-1) liberates carbon monoxide under low-intensity visible light, with crystal size from 260 nm to 1 mm setting the dose.
Evidence for the claim as stated.
Loading that TGA might have reported as residual mass is instead given as a size/photochemistry knob. Immobilised Mn carbonyls in UiO-67-type bpy MOFs change crystal size from 260 nm to 1 mm, which changes loading and photoefficiency of visible-light CO release; cells on a polymer film of the MOF see intracellular CO after irradiation. NIR deep-tissue delivery is not shown. A chitosan–xanthan hydrogel similarly quotes 90.64% acyclovir DEE and 87.57% release at pH 7.4 (FCX8 76.83% DEE) rather than a TGA drug-loading step.
Evidence for the claim as stated.
Composition from TGA-style thinking (how much is inorganic, how much is cargo) is not the function. MOF crystal size 260 nm–1 mm changes CO-photo-loading; hydrogel %DEE is a wet assay; Zn hydrate formula is elemental analysis. None of those papers' headline numbers are a TGA onset, and CO remains a toxic gas if mis-dosed.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Composition from TGA-style thinking (how much is inorganic, how much is cargo) is not the function. MOF crystal size 260 nm–1 mm changes CO-photo-loading; hydrogel %DEE is a wet assay; Zn hydrate formula is elemental analysis. None of those papers' headline numbers are a TGA onset, and CO remains a toxic gas if mis-dosed.
Related papers in this topic
Same topic cluster — not a recommendation engine.