OSA severity and cardiovascular risk
In >10,000 sleep-study patients, higher apnea–hypopnea burden predicted cardiovascular events and death over years of follow-up.
Source
Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study
Study at a glance
- Design
- Cohort — Diagnostic polysomnography cohort linked to administrative CV outcomes
- N
- N=10149 · 10,149 of 11,596 first diagnostic sleep studies linked to admin data (88%)
- Population
- Adults undergoing diagnostic polysomnography
- Outcome
- Composite cardiovascular events and mortality
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OSA severity and cardiovascular risk
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10,149 included.
Between January 1, 1994 and December 31, 2010, 11,596 individuals underwent a first diagnostic sleep study and 10,149 (88%) were linked to administrative data sets and included in our analyses (). sho
1,172 (11.5%) had composite events.
Over a median follow-up of 68 months, 1,172 (11.5%) participants experienced a composite outcome, giving an incidence rate of 2 per 100 person-years. Event
What they did
Adults undergoing diagnostic polysomnography were linked to administrative outcomes; investigators modelled AHI and oxygen-desaturation metrics against a composite of CV events and mortality.
What they found
Of 10,149 included patients, 11.5% had a composite event over median 68 months. Higher AHI related to higher hazard (e.g., HR 1.49 comparing high vs low AHI in univariate modelling).
The limits
What it doesn't show
Observational sleep-lab cohorts have referral bias; CPAP claims were not clearly protective in adjusted models.
Key terms
- OSA
- Obstructive sleep apnea.
- AHI
- Apnea–hypopnea index (events/hour).
- TST90
- Sleep time with SpO2 <90%.
- Composite CV outcome
- Combined CV hospitalisation/events and death.
- Polysomnography
- Overnight sleep study.
- Hazard ratio
- Relative instantaneous event risk.
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Analysed N:
Common questions
Analysed N?
10,149.
Events?
1,172 (11.5%).
Follow-up?
68 months median.
AHI contrast HR?
1.49 univariate.
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