Topic
Cardiovascular research, explained
23 open-access cardiovascular studies, each with a flashcard deck and a quiz.
- COVID-19 death risk and comorbidities
In 31,461 US adults with COVID-19, older age, male sex, Black race, and several comorbidities including heart disease predicted higher mortality.
- OSA severity and cardiovascular risk
In >10,000 sleep-study patients, higher apnea–hypopnea burden predicted cardiovascular events and death over years of follow-up.
- Should very old frail people still get blood-pressure pills?
In 2,656 HYVET participants aged 80+, frailty did not cancel the benefit of indapamide±perindopril: stroke HR 0.64 and CV-event HR 0.59, with no significant FI×treatment interaction.
- Literacy-friendly HF self-care trial
A literacy-sensitive outpatient heart failure education program improved knowledge and self-efficacy but did not clearly cut hospitalizations or quality-of-life scores versus usual care.
- Does higher BMI causally raise heart disease risk?
Genetic instruments for BMI suggest a causal increase in ischemic heart disease risk larger than simple observational estimates.
- Olive oil intake and CVD risk
Higher olive oil intake tracked lower major CVD events and cardiovascular death in PREDIMED participants.
- How much dementia could prevention still avert?
In Rotterdam cohorts, about one quarter to one third of dementia cases were potentially attributable to modifiable risks—and that share did not shrink over two decades.
- How broadly does smoking raise heart and vessel disease risk?
In a large Australian cohort, current smoking raised risk across nearly all CVD subtypes—especially peripheral arterial disease—and quitting lowered risk.
- How does smoking change risk across CVD subtypes?
In ~188k Australians, current smoking raised risk for most CVD subtypes—often at least doubling AMI, stroke, and heart failure—and quitting early cut excess risk.
- Phone telemonitoring after heart-failure flare
Home mobile-phone telemonitoring after acute heart-failure decompensation cut primary events and hospital days versus usual care.
- Does the inflammation marker CRP actually cause disease?
People born with gene variants that raise their C-reactive protein were not at higher risk of almost any of 32 diseases linked to high CRP, suggesting CRP is mostly a marker rather than a cause, with a surprising lower risk of schizophrenia.
- How well did England's midlife heart-risk check work at first?
In its first four years England's NHS Health Check reached a growing but still small share of eligible adults, found many new cases of high blood pressure, and started statins in only about a fifth of the high-risk people it identified.
- Does coconut oil raise LDL like butter?
In 96 healthy adults, 50 g/day butter for 4 weeks raised LDL-C by ~0.4 mmol/L versus coconut or olive oil; coconut oil did not differ from olive oil on LDL and raised HDL-C.
- Do comorbidity patterns predict outcomes in Asian heart failure?
Asian heart-failure patients fell into five natural comorbidity clusters, and a 'lean diabetic' group had the worst quality of life and nearly three times the one-year rate of death or hospitalisation of the youngest, healthiest group.
- Higher weight-adjusted waist index ties to more stroke in NHANES
In 23,389 US NHANES adults (2011–2020), higher weight-adjusted waist index (WWI) associated with greater stroke prevalence—fully adjusted OR 1.25 per unit and 62% higher odds in the top vs bottom quartile.
- Does breathing at your resonance frequency actually improve HRV and blood pressure?
In 95 randomized students, 15 minutes of resonance-frequency breathing raised positive mood and LF/HF HRV and lowered PASAT systolic BP versus sitting quietly; RF+1 was in between.
- Does an inflammatory diet raise stroke risk?
Higher dietary inflammatory index scores associated with greater stroke odds in NHANES adults.
- Do TyG and TyG-WHtR predict death and CVD in NAFLD?
In 6,627 NHANES adults with NAFLD, TyG-WHtR better predicted all-cause death, CVD death, and heart failure, while the TyG index tracked total CVD, CHD, and angina.
- Do remnant cholesterol and triglycerides cause cardiometabolic multimorbidity?
In >300,000 UK Biobank participants, higher remnant cholesterol and triglycerides tracked—and MR supported a causal role in—progression to cardiometabolic multimorbidity, especially IHD plus type 2 diabetes.
- Do people who feel more tired die sooner?
Middle-aged and older adults who reported the most fatigue were more likely to die over the next 16 years, mainly from heart and circulatory disease, even after accounting for many other health factors.
- How do AF comorbidity patterns change care and outcomes?
In 32,560 AF patients, six comorbidity phenotypes ranged from low complexity to high complexity, with cardiometabolic/high-complexity groups facing higher event risk despite more anticoagulation.
- How might dapagliflozin ease diabetic stiff hearts?
In 30 rabbits, dapagliflozin lessened diabetes-related diastolic dysfunction and fibrosis by downregulating SGK1 and ENaC, with matching H9C2 cell results.
- Can a Rubia extract protect hypoperfused rat brains?
In 70 SD rats with 2VO hypoperfusion, 30-day RY-A gavage improved cognition and raised ferroptosis-guard proteins (SLC7A11, GPX4) via System Xc-/GSH/GPX4.