Cell signalling
HSP90 family across kingdoms
Open access · cc by · source: Europe PMC
Comparative genomics maps 103 HSP90-family genes across 32 genomes and deep phylogenetic diversity.
Study at a glance
- Design
- Computational / modelling — Multi-kingdom survey of HSP90 homologs and phylogeny across sequenced genomes
- N
- N=32 · 32 genomes yielding 103 HSP90-family genes (87 functional, 16 pseudogenes); phylogeny used 197 sequences
- Population
- Sequenced genomes spanning Archaea, Bacteria, and Eukarya
- Outcome
- Distribution and evolutionary relationships of the HSP90 gene family
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
103 genes on 32 genomes (87 functional, 16 pseudogenes); vertebrates have the largest counts; Archaea nearly lack HSP90.
Methodology
Surveyed genomes for HSP90 homologs, classified functional genes vs pseudogenes, and built multi-kingdom phylogenies.
Limitations
Does not experimentally mutate each homolog’s chaperone clients.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
103 genes on 32 genomes (87 functional, 16 pseudogenes); vertebrates have the largest counts; Archaea nearly lack HSP90.
Evidence for the claim as stated.
A multi-kingdom HSP90 survey found 103 genes on 32 genomes (87 functional, 16 pseudogenes). Vertebrates had the largest counts; Archaea nearly lack HSP90. The phylogeny classifies homologs and pseudogenes; it does not mutate each homolog's chaperone clients.
Evidence for the claim as stated.
These papers do not build the same kind of tree. HSP90 and MYB papers classify gene families; the immune-gene paper scans orthologs for repeated positive selection (~14% selected in all tests); Aspergillus and Listeria papers mix clade phylogeny with pan-genome gene content; turtle and Medicago papers are organismal genomes whose phylogeny is background for physiology or breeding. A student who treats every 'phylogenetic analysis' hit as a species tree will misread the result.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
These papers do not build the same kind of tree. HSP90 and MYB papers classify gene families; the immune-gene paper scans orthologs for repeated positive selection (~14% selected in all tests); Aspergillus and Listeria papers mix clade phylogeny with pan-genome gene content; turtle and Medicago papers are organismal genomes whose phylogeny is background for physiology or breeding. A student who treats every 'phylogenetic analysis' hit as a species tree will misread the result.
- Supports · MYB transcription-factor families in plants
- Supports · Why do immune genes keep evolving across tetrapods?
- Supports · How open is the Listeria pan-genome?
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