HSP90 family across kingdoms
Comparative genomics maps 103 HSP90-family genes across 32 genomes and deep phylogenetic diversity.
Source
Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms
What they did
Surveyed genomes for HSP90 homologs, classified functional genes vs pseudogenes, and built multi-kingdom phylogenies.
What they found
103 genes on 32 genomes (87 functional, 16 pseudogenes); vertebrates have the largest counts; Archaea nearly lack HSP90.
The limits
What it doesn't show
Does not experimentally mutate each homolog’s chaperone clients.
Key terms
- HSP90
- Heat-shock protein 90 chaperone family.
- Molecular chaperone
- Protein helping folding/stability of clients.
- Pseudogene
- Nonfunctional gene remnant.
- Comparative genomics
- Cross-species genome comparison.
- Phylogeny
- Evolutionary tree of related genes.
- Client protein
- Substrate stabilized/folded by HSP90.
Flashcards
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Genes total:
Common questions
Genes on 32 genomes?
103.
Functional vs pseudo?
87 vs 16.
Highest counts?
Vertebrates.
Archaea?
Nearly absent (one-like case noted).
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