HSP90 family across kingdoms

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Comparative genomics maps 103 HSP90-family genes across 32 genomes and deep phylogenetic diversity.

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Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

Chen B, Zhong D, Monteiro A · BMC genomics · 2006

doi.org/10.1186/1471-2164-7-156 Read the full paper ↗241 citationscc by

Study at a glance

Design: Computational / modelling — Multi-kingdom survey of HSP90 homologs and phylogeny across sequenced genomes
N: N=32 · 32 genomes yielding 103 HSP90-family genes (87 functional, 16 pseudogenes); phylogeny used 197 sequences
Population: Sequenced genomes spanning Archaea, Bacteria, and Eukarya
Outcome: Distribution and evolutionary relationships of the HSP90 gene family

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HSP90 family across kingdoms

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103 HSP90-family genes on 32 genomes.

There are a total of 103 genes belonging to the HSP90 family on the 32 genomes analyzed (Table , Table ).

87 functional genes and 16 pseudogenes.

Out of these 103 genes, 87 are putative functional genes and 16 are pseudogenes, based on functional motif/domain analysis (see the following section).

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What they did

Surveyed genomes for HSP90 homologs, classified functional genes vs pseudogenes, and built multi-kingdom phylogenies.

What they found

103 genes on 32 genomes (87 functional, 16 pseudogenes); vertebrates have the largest counts; Archaea nearly lack HSP90.

The limits

What it doesn't show

Does not experimentally mutate each homolog’s chaperone clients.

Key terms

HSP90: Heat-shock protein 90 chaperone family.
Molecular chaperone: Protein helping folding/stability of clients.
Pseudogene: Nonfunctional gene remnant.
Comparative genomics: Cross-species genome comparison.
Phylogeny: Evolutionary tree of related genes.
Client protein: Substrate stabilized/folded by HSP90.

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Genes total:

Common questions

Genes on 32 genomes?

103.

Functional vs pseudo?

87 vs 16.

Highest counts?

Vertebrates.

Archaea?

Nearly absent (one-like case noted).