Depression treatment
Deprexis online therapy reduced depression scores
Open access · cc by · source: Europe PMC
An integrative online program (Deprexis) improved BDI depression symptoms versus delayed treatment in a large German internet RCT.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Multiple studies in this library examine depression treatment with empirical patient or population outcomes rather than opinion alone.
Evidence for the claim as stated.
Immediate treatment improved ~5.4 BDI points (d=0.58) with a significant condition×time interaction; delayed group showed essentially no BDI change over the same interval.
Evidence for the claim as stated.
Effect sizes and settings differ across depression treatment studies — digital vs clinic, trial vs observational — so results should not be pooled casually.
Evidence for the claim as stated.
Adjunctive smartphone CBT in antidepressant-refractory major depression used ITT on 164 randomised participants: at week 9 the Kokoro-app arm scored about 2.5 PHQ-9 points lower (SMD 0.40) and was more likely to meet response criteria, while remission and side-effect differences were not significant. Deprexis, in 396 adults recruited online, improved BDI by about 5.4 points (d=0.58) versus delayed treatment. Neither ITT result is a head-to-head against face-to-face CBT or a long-term relapse trial.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Effect sizes and settings differ across depression treatment studies — digital vs clinic, trial vs observational — so results should not be pooled casually.
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Study at a glance
- Design
- RCT — Immediate Deprexis vs delayed treatment; online recruitment
- N
- N=396 · 81% assigned to immediate treatment
- Population
- Adults with depression symptoms recruited online for Deprexis
- Outcome
- BDI change over time (condition × time)
Structured fields used in claim comparison tables when every cited study has a complete layer.
Inspect source passages
Deprexis online therapy reduced depression scores
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
Immediate group improved 5.4 BDI points (d=0.58).
Based on estimated marginal means, the immediate-treatment group improved 5.4 BDI points (from 26.72 to 21.30), which corresponded to a pre-post effect size of d = 0.58.
396 individuals were included; 81% immediate treatment.
As summarized in , a total of 396 individuals was included in the study, of which 81% were assigned to the immediate-treatment condition and 19% to the delayed-treatment condition.
Key findings
Immediate treatment improved ~5.4 BDI points (d=0.58) with a significant condition×time interaction; delayed group showed essentially no BDI change over the same interval.
Methodology
Researchers randomized 396 adults recruited online to immediate Deprexis treatment or delayed treatment and compared BDI and functioning over time.
Limitations
How Deprexis compares head-to-head with face-to-face CBT, or effects in people without internet access/forum recruitment.
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