Depression treatment
Mediterranean diet and depression risk
Open access · cc by · source: Europe PMC
Overall Mediterranean diet assignment did not significantly reduce depression; a nuts arm suggested benefit in diabetes subgroup analyses.
How this study connects
Role on claims
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224 depression cases (median 5.4 years). Merged MD HR 0.85 (NS). MD-nuts nonsignificantly inverse overall; significant benefit in DM2 subgroup.
Evidence for the claim as stated.
When depression is not the trial's original primary endpoint, a Cox HR below 1 is easy to over-read. PREDIMED's merged Mediterranean-diet HR for incident depression was 0.85 and not significant; a nuts-arm benefit appeared in a diabetes subgroup after 224 cases over a median 5.4 years.
Evidence for the claim as stated.
Study at a glance
- Design
- RCT — PREDIMED Mediterranean-diet arms vs control; incident depression, including a diabetes subgroup
- N
- N=2513 · Analytic sample reported for the depression analysis
- Population
- PREDIMED adults at high cardiovascular risk
- Outcome
- Incident depression after assignment to Mediterranean diet with nuts vs control, especially among participants with type 2 diabetes
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Mediterranean diet and depression risk
These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.
224 new depression cases.
We identified 224 new cases of depression during the follow-up period (median 5.4 years).
Merged MD HR 0.85.
When both MDs were merged together and analyzed as a single group, no significant association was found between the MD intervention and depression risk (multivariate HR = 0.85; 95% CI 0.64 to 1.13). R
Key findings
224 depression cases (median 5.4 years). Merged MD HR 0.85 (NS). MD-nuts nonsignificantly inverse overall; significant benefit in DM2 subgroup.
Methodology
PREDIMED randomised high-CVD-risk adults to MD-EVOO, MD-nuts, or low-fat control and tracked incident depression.
Limitations
Depression was not the original primary endpoint; subgroups can be chance findings.
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