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Neurodegeneration

Does T2DM impair glymphatic flow on DTI-ALPS?

Yang G, Deng N, Liu Y, et al. · Frontiers in human neuroscience · 2020

Open access · cc by · source: Europe PMC

In 30 adults, longer T2DM history tracked with lower ALPS-index values, suggesting reduced perivascular water diffusivity.

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Study at a glance

Design
Case-control — DTI-ALPS comparison of T2DM duration groups vs controls
N
N=30 · 10 ≥10 y T2DM, 10 <10 y T2DM, 10 controls
Population
Adults with type 2 diabetes and age-matched controls imaged at lateral ventricle body plane
Outcome
Directional diffusivities and ALPS-index as glymphatic activity markers

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Key findings

ALPS-index and perivascular-aligned diffusivity differed by T2DM history (key contrasts P < 0.001); authors interpret lower ALPS as glymphatic impairment.

Methodology

Calculated directional diffusivities and ALPS-index from DTI at the lateral ventricle body in ≥10 y T2DM, <10 y T2DM, and controls (n=10 each).

Limitations

Causal proof that diabetes damages glymphatics, or that ALPS equals true CSF clearance; sample is small and cross-sectional.

How this study connects

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