Metabolism
Salmon fat-cell differentiation transcriptome
Open access · cc by · source: Europe PMC
Atlantic salmon adipose SVF cells progress through proliferative then adipogenic expression programs.
Study at a glance
- Design
- Animal / in-vitro — Microarray time course of cultured salmon adipose-derived stromo-vascular cells during adipogenesis
- N
- In-vitro differentiation days 1–30; no single primary animal analytic N in stored text
- Population
- Atlantic salmon adipose-derived stromo-vascular fraction cultures
- Outcome
- Gene-expression trajectory from MSC-like cells to mature adipocytes
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
Early MSC/immune/perivascular signatures give way to lipid-accumulating adipocyte phenotypes by day 30.
Methodology
Cultured aSVF, induced adipogenesis, and profiled microarray expression across differentiation days.
Limitations
In vitro culture may not match in vivo adipose niches perfectly.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Atlantic salmon adipose stromal-vascular cultures were induced to adipogenesis and profiled by microarray: early MSC/immune/perivascular signatures gave way to lipid-accumulating adipocyte phenotypes by day 30. EM of lipid droplets, if used, is a differentiation check; in-vitro culture may not match in-vivo adipose niches.
Evidence for the claim as stated.
Only the caveolar paper is clearly an ultrastructure-of-a-coat study. GPCR work compares 142 inactive and 27 active deposited structures; APEX2 is proteomics; salmon work is a 30-day transcriptome of fat-cell differentiation; Bt OMV uptake is live light-microscopy trafficking. Calling all five 'electron microscopy papers' overstates shared methods.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
Only the caveolar paper is clearly an ultrastructure-of-a-coat study. GPCR work compares 142 inactive and 27 active deposited structures; APEX2 is proteomics; salmon work is a 30-day transcriptome of fat-cell differentiation; Bt OMV uptake is live light-microscopy trafficking. Calling all five 'electron microscopy papers' overstates shared methods.
- Supports · What proteins build the caveolar coat?
- Supports · Shared class A GPCR activation path
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- Supports · How do gut-bacteria vesicles enter host cells?
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