Salmon fat-cell differentiation transcriptome

Atlantic salmon adipose SVF cells progress through proliferative then adipogenic expression programs.

Source

Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes

Todorcević M, Skugor S, Krasnov A, et al. · BMC genomics · 2010

doi.org/10.1186/1471-2164-11-39 Read the full paper ↗42 citationscc by

Study at a glance

Design: Animal / in-vitro — Microarray time course of cultured salmon adipose-derived stromo-vascular cells during adipogenesis
N: In-vitro differentiation days 1–30; no single primary animal analytic N in stored text
Population: Atlantic salmon adipose-derived stromo-vascular fraction cultures
Outcome: Gene-expression trajectory from MSC-like cells to mature adipocytes

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Salmon fat-cell differentiation transcriptome

These passages occur verbatim in the stored paper text. They support the points listed below; they do not verify every statement in the explanation.

Atlantic salmon.

WAT) in mammals is now recognized as a highly active endocrine tissue producing numerous secretory proteins, including adipokines, a suite of small signalling proteins specifically produced in WAT [,].

Adipose-derived stromo-vascular fraction.

In salmonid fish, precursor cells differentiate into adipocytes continuously [], however, the exact origin of preadipocytes is not known.

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What they did

Cultured aSVF, induced adipogenesis, and profiled microarray expression across differentiation days.

What they found

Early MSC/immune/perivascular signatures give way to lipid-accumulating adipocyte phenotypes by day 30.

The limits

What it doesn't show

In vitro culture may not match in vivo adipose niches perfectly.

Key terms

aSVF: Adipose stromo-vascular fraction.
Adipocyte: Fat-storing cell.
Preadipocyte: Adipocyte precursor.
Oil Red O: Lipid stain.
MSC: Mesenchymal stem/stromal cell.
Adipokine: Adipose signaling protein.

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Common questions

Species?

Atlantic salmon.

Cells?

Adipose SVF.

Endpoint?

Adipocytes.

Readout?

Expression + lipids.