Salmon fat-cell differentiation transcriptome
Atlantic salmon adipose SVF cells progress through proliferative then adipogenic expression programs.
Source
Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes
What they did
Cultured aSVF, induced adipogenesis, and profiled microarray expression across differentiation days.
What they found
Early MSC/immune/perivascular signatures give way to lipid-accumulating adipocyte phenotypes by day 30.
The limits
What it doesn't show
In vitro culture may not match in vivo adipose niches perfectly.
Key terms
- aSVF
- Adipose stromo-vascular fraction.
- Adipocyte
- Fat-storing cell.
- Preadipocyte
- Adipocyte precursor.
- Oil Red O
- Lipid stain.
- MSC
- Mesenchymal stem/stromal cell.
- Adipokine
- Adipose signaling protein.
Flashcards
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Topic:
Common questions
Species?
Atlantic salmon.
Cells?
Adipose SVF.
Endpoint?
Adipocytes.
Readout?
Expression + lipids.
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