Gene expression
Multi-tissue networks behind obesity biology
Open access · cc by · source: Europe PMC
Adipose–hypothalamus coexpression subnetworks, including circadian genes, associate with obesity-related biology beyond single-tissue views.
Key findings
Several adipose–hypothalamus TTC subnetworks map to biological functions; a central C2 subnetwork is enriched for obesity- and circadian-related genes (e.g., Arntl, Per1/2).
Methodology
Built multi-tissue coexpression networks integrating expression across tissues to find cross-tissue subnetworks linked to disease traits.
Limitations
Network enrichment is not a clinical treatment trial; causality of each edge remains to be tested.
How this study connects
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