Neural oscillations
What can closed-loop brain stimulation do?
Open access · cc by · source: Europe PMC
A PRISMA review of 76 studies maps DBS, TMS, tDCS, tACS, and optogenetics closed-loop BCIs aimed at restoring neurological function.
Study at a glance
- Design
- Other — PRISMA systematic review of closed-loop BCI / brain-stimulation studies (not a new trial)
- N
- N=76 · 76 included articles from 319 screened candidates
- Population
- Published primary studies of closed-loop stimulation in humans or animals across neurological/psychiatric indications
- Outcome
- Mapped stimulation modalities (DBS/TMS/tDCS/tACS/optogenetics) and claimed functional improvements
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
Literature spans neurodegenerative and psychiatric uses; authors argue closed-loop approaches can restore/rehabilitate function, with modality-specific trade-offs (e.g., optogenetics still preclinical for humans).
Methodology
Searched databases with a closed-loop BCI + stimulation + disease string, applied inclusion/exclusion criteria, and extracted participant, method, and disease features.
Limitations
Pooled effect sizes or a new head-to-head trial; narrative synthesis of heterogeneous primary studies.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Not yet placed on a claim. This paper has study layers, but no concept page yet cites it as support, challenge, or qualifier.
Related papers in this topic
Same topic cluster — not a recommendation engine.