Persistent pollutants
Cord-blood PFBS linked to preeclampsia in Shanghai
Open access · cc by · source: Europe PMC
Among Shanghai births, higher standardized cord PFBS associated with preeclampsia (AOR 1.81) and overall hypertensive disorders of pregnancy (AOR 1.64) in a dose-response pattern.
Study at a glance
- Design
- Cohort — Shanghai delivery cohort with cord-blood PFAS and recorded hypertensive disorders of pregnancy
- N
- N=687 · 687 women delivering singletons at two Shanghai hospitals (13 excluded for missing covariates in some models)
- Population
- Women delivering at two Shanghai hospitals, 2011–2012
- Outcome
- Hypertensive disorders of pregnancy and preeclampsia related to cord PFAS (esp. PFBS)
Structured fields used in claim comparison tables when every cited study has a complete layer.
Key findings
HDP, preeclampsia, and gestational hypertension rates were 6.1%, 2.8%, and 3.3%. PFOA was the highest median PFAS (6.98 ng/ml) but PFBS (median 0.047 ng/ml) was selected for HDP/preeclampsia. AOR 1.64 for HDP and 1.81 for preeclampsia per standardized PFBS unit.
Methodology
Authors recruited women delivering at two Shanghai hospitals, quantified eight PFAS in cord blood, classified HDP/preeclampsia from records, and used elastic-net then unpenalized logistic models with confounder adjustment.
Limitations
Cord blood is not a full pregnancy-long exposure history, and observational AORs cannot prove PFBS causes preeclampsia.
How this study connects
Role on claims
Each row is a claim on a concept or method page where this paper supports, challenges, or qualifies the statement. Roles are hand-checked — not a model guess.
Shanghai deliveries quantified eight PFAS in cord blood. HDP, preeclampsia and gestational hypertension rates were 6.1%, 2.8% and 3.3%. PFOA had the highest median (6.98 ng/ml), but elastic-net selected PFBS (median 0.047 ng/ml) for HDP/preeclampsia. Unpenalized logistic AORs were 1.64 for HDP and 1.81 for preeclampsia per standardised PFBS unit. Cord blood is not a full pregnancy-long exposure history.
Evidence for the claim as stated.
PFAS logistic results do not agree on which compound or outcome carries the signal. Ronneby's high-cholesterol OR is about 1.3 per ln-PFAS in a PFOS/PFHxS-dominated mixture. Shanghai selected low-concentration PFBS (AOR 1.64/1.81) while the highest-median compound, PFOA at 6.98 ng/ml, was not the selected HDP predictor. Age-5 overweight associations differed by country. A single 'PFAS odds ratio' is not portable.
Evidence for the claim as stated.
Open questions
Tensions this paper is part of
From concept pages' “where studies disagree.” Disagreement means the same question; scope means different assays, populations, or outcomes.
PFAS logistic results do not agree on which compound or outcome carries the signal. Ronneby's high-cholesterol OR is about 1.3 per ln-PFAS in a PFOS/PFHxS-dominated mixture. Shanghai selected low-concentration PFBS (AOR 1.64/1.81) while the highest-median compound, PFOA at 6.98 ng/ml, was not the selected HDP predictor. Age-5 overweight associations differed by country. A single 'PFAS odds ratio' is not portable.
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