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Do priors reshape motor preparation before you act?

Tarasi L, Tabarelli de Fatis C, Covelli M, et al. · iScience · 2025

Open access · cc by · source: Europe PMC

In 62 adults, probabilistic cues biased decisions and inhibited prior-incongruent motor cortex excitability; MEP modulators vs non-modulators tracked believer vs empiricist styles.

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Do priors reshape motor preparation before you act?

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62 participants (37 female, 18–32).

62 participants (37 female, age range 18–32) took part in the study

Significant cue effect on response criterion.

Signal detection theory (SDT) analysis ( Figure 2 A) revealed a significant cue effect on response criterion (i.e., the tendency to respond “right” or “left”; F 2,122 = 37.96
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Key findings

Cues shifted decision criterion; prior expectations inhibited motor regions coding incongruent responses; trial-by-trial MEPs related to bias; schizotypal/autistic traits linked to believer/empiricist styles.

Methodology

Participants did an RDM discrimination task with informative/uninformative cues while bilateral M1 TMS elicited MEPs at multiple peri-stimulus times.

Limitations

Not a clinical treatment study; styles are correlational with traits, not diagnostic categories.

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