Innate immunity
Was innate immunity already complex in early animals?
Open access · cc by · source: Europe PMC
Anthozoan cnidarians retain much ancestral metazoan immune/signaling complexity; flies and worms lost many components.
Key findings
Morphologically simple cnidarians preserve much ancestral complexity (e.g., Wnt/immune-related pathways); Drosophila/C. elegans show extensive gene loss; understanding cnidarian immunity also matters for coral decline.
Methodology
Surveyed innate-immunity gene families in cnidarian genomes/ESTs (Acropora, Nematostella) versus bilaterian models.
Limitations
Does not functionally prove every predicted receptor’s ligand in vivo.
How this study connects
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