Topic
Protein trafficking research, explained
7 open-access protein trafficking studies, each with a flashcard deck and a quiz.
- Mapping the faces of mitochondria and ER
APEX2 proximity biotinylation yields high-quality proteomic maps of cytosol-facing outer mitochondrial and ER membranes in living human cells.
- How do proteins find plasmodesmata?
PDLP1 is a type I membrane protein targeted to plasmodesmata; altering PDLP dosage changes GFP cell-to-cell trafficking.
- What proteins build the caveolar coat?
Caveolins and cavins purify as a caveolar coat complex with Cavin 1 as a core trimeric component.
- SNARE timing in sperm acrosome exocytosis
Sperm acrosome exocytosis proceeds via ordered SNARE assembly/disassembly around intra-acrosomal Ca2+ release.
- How MC4R variants scramble receptor trafficking
Obesity-linked MC4R mutations disrupt plasma-membrane localization, endocytosis and β-arrestin pathways beyond classical cAMP loss-of-function.
- Spike glycosylation and palmitoylation trafficking
Glycosylation motifs and cysteine palmitoylation steer SARS-CoV-2 spike maturation, Golgi trafficking, and fusion.
- How does monoubiquitin turn down Rab5?
Rab5 is monoubiquitinated at specific lysines; ubiquitin at K140/K165 disrupts effector binding and downregulates endocytic trafficking.