What proteins build the caveolar coat?
Caveolins and cavins purify as a caveolar coat complex with Cavin 1 as a core trimeric component.
Source
Molecular composition and ultrastructure of the caveolar coat complex
What they did
Purified caveolar coat proteins and used quantitative composition plus ultrastructure to model coat stoichiometry.
What they found
Caveolins and cavins form one complex excluding EHD2/pacsin 2; Cavin 1 is a core component with evidence for trimers.
The limits
What it doesn't show
Composition model is not a full in vivo dynamics movie of every cell type.
Key terms
- Caveolae
- Flask-shaped plasma-membrane invaginations.
- Caveolin
- Integral membrane protein essential for caveolae.
- Cavin
- Coat proteins cooperating with caveolins.
- Coat complex
- Stable multiprotein assembly forming the caveolar coat.
- Stoichiometry
- Relative molecular counts in the complex.
Flashcards
Want these cards to stick?
Save the deck to NoteFren and study it with spaced repetition.
Quiz yourself
Coat complex includes:
Common questions
What is excluded from the coat complex?
EHD2 and pacsin 2.
Core cavin?
Cavin 1.
Cavin 1 oligomer?
Evidence for a trimer.
Why care?
Defines molecular build of caveolae.
More on Protein trafficking