What proteins build the caveolar coat?
Caveolins and cavins purify as a caveolar coat complex with Cavin 1 as a core trimeric component.
Source
Molecular composition and ultrastructure of the caveolar coat complex
Study at a glance
- Design
- Animal / in-vitro — Biochemical purification and ultrastructure of caveolar coat proteins
- N
- Structural/biochemical coat stoichiometry study — no single sample N
- Population
- Caveolar coat complexes (caveolins/cavins)
- Outcome
- Molecular composition and ultrastructure of the caveolar coat
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What proteins build the caveolar coat?
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What complex do caveolins and cavins form?
caveolins and cavins can be purified as a single species of protein complex that excludes EHD2 and pacsin 2.
What proteins are excluded from that complex?
that excludes EHD2 and pacsin 2. We term this complex the caveolar coat complex.
What they did
Purified caveolar coat proteins and used quantitative composition plus ultrastructure to model coat stoichiometry.
What they found
Caveolins and cavins form one complex excluding EHD2/pacsin 2; Cavin 1 is a core component with evidence for trimers.
The limits
What it doesn't show
Composition model is not a full in vivo dynamics movie of every cell type.
Key terms
- Caveolae
- Flask-shaped plasma-membrane invaginations.
- Caveolin
- Integral membrane protein essential for caveolae.
- Cavin
- Coat proteins cooperating with caveolins.
- Coat complex
- Stable multiprotein assembly forming the caveolar coat.
- Stoichiometry
- Relative molecular counts in the complex.
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Coat complex includes:
Common questions
What is excluded from the coat complex?
EHD2 and pacsin 2.
Core cavin?
Cavin 1.
Cavin 1 oligomer?
Evidence for a trimer.
Why care?
Defines molecular build of caveolae.
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